News & Views | Published:

Friendly fire: anti-cytokine antibodies elicited by microbes

Nature Medicine volume 22, pages 973975 (2016) | Download Citation

A recent study suggests that exposure to the mold Aspergillus induces the production of antibodies that neutralize interferon-γ (IFN-γ), which increases the risk of mycobacterial disease.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , & Semin. Immunol. 26, 454–470 (2014).

  2. 2.

    et al. Medicine 95, e3927 (2016).

  3. 3.

    et al. N. Engl. J. Med. 367, 725–734 (2012).

  4. 4.

    Nat. Med. 22, 994–1001 (2016).

  5. 5.

    , et al. J. Allergy Clin. Immunol. 137, 945–948.e8 (2016).

  6. 6.

    Microbes Infect. 2, 1579–1590 (2000).

  7. 7.

    et al. J. Immunol. 175, 4769–4776 (2005).

  8. 8.

    , & N. Engl. J. Med. 349, 2527–2539 (2003).

  9. 9.

    et al. J. Immunol. 190, 3959–3966 (2013).

  10. 10.

    et al. J. Exp. Med. 207, 291–297 (2010).

  11. 11.

    et al. J. Clin. Invest. 125, 4135–4148 (2015).

Download references

Acknowledgements

This work was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Disease, NIH.

Author information

Affiliations

  1. Luigi D. Notarangelo is in the Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

    • Luigi D Notarangelo
  2. Steven M. Holland is in the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

    • Steven M Holland

Authors

  1. Search for Luigi D Notarangelo in:

  2. Search for Steven M Holland in:

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Luigi D Notarangelo or Steven M Holland.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm.4175

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing