SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

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Figure 1: SAMHD1-mediated HIV-1 restriction in cells does not involve RNase activity.

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Acknowledgements

This work was supported by NIH grants AI104483 and CA181997 (L.W.), AI114826 (J.S.Y.), AI102778 (Y.X.), AI120845 (X.J.) and AI049781 and GM104198 (B.K.). The authors thank N. Landau for the pLenti-puro plasmids, and J. Hach and S.H. Kim for technical assistance. The antibody to HIV-1 p24 Gag (clone #24-2) and nevirapine were obtained from the NIH AIDS Reagent Program.

Author information

J.M.A., C.S.G., S.d.S., J.S.Y., Y.X. and L.W. designed the study and wrote the manuscript. J.M.A., C.S.G., S.d.S., C.T., X.J. and C.S. performed the experiments and analyses. J.M.A, C.S.G., S.d.S., J.S.Y., Y.X., B.K. and L.W. analyzed the data. All authors discussed the data and approved the manuscript.

Correspondence to Li Wu.

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The authors declare no competing financial interests.

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Antonucci, J., St. Gelais, C., de Silva, S. et al. SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity. Nat Med 22, 1072–1074 (2016) doi:10.1038/nm.4163

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