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CBLB ubiquitin ligase: a major regulator of antifungal immunity

Nature Medicine volume 22, pages 834835 (2016) | Download Citation

Little is known about the regulatory mechanisms of antifungal host defense. Two complementary studies show that the E3 ubiquitin ligase CBLB targets dectin-1 and dectin-2 for degradation, and thus exerts a strong anti-inflammatory effect.

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Acknowledgements

M.G.N. was supported by an ERC Consolidator Grant (#310372) and a Spinoza Grant of the Netherlands Organization for Scientific Research (NWO). F.L.V. was supported by the ERA-Net for Research Programs on Rare Diseases, 'EURO-CMC'.

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Affiliations

  1. Frank L. van de Veerdonk and Mihai G. Netea are in the Department of Internal Medicine, Radboud University Medical Center, and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

    • Frank L van de Veerdonk
    •  & Mihai G Netea

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Competing interests

The authors declare no competing financial interests.

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Correspondence to Mihai G Netea.

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DOI

https://doi.org/10.1038/nm.4160

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