The role of muscle stem cell–niche interactions during aging

Two recent studies have shown that alterations in muscle stem cell–niche interactions during aging underlie the functional decline in regenerative potential. The reconstitution of this communication restores stem cell function and enhances skeletal muscle repair.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Targeting MuSC-niche interactions improves aged MuSC self-renewal and skeletal muscle repair.

Marina Corral Spence/Nature Publishing Group

References

  1. 1

    Chakkalakal, J.V., Jones, K.M., Basson, M.A. & Brack, A.S. Nature 490, 355–360 (2012).

  2. 2

    Price, F.D. et al. Nat. Med. 20, 1174–1181 (2014).

  3. 3

    Tierney, M.T. et al. Nat. Med. 20, 1182–1186 (2014).

  4. 4

    Bernet, J.D. et al. Nat. Med. 20, 265–271 (2014).

  5. 5

    Cosgrove, B.D. et al. Nat. Med. 20, 255–264 (2014).

  6. 6

    García-Prat, L. et al. Nature 529, 37–42 (2016).

  7. 7

    Sousa-Victor, P. et al. Nature 506, 316–321 (2014).

  8. 8

    Rozo, M., Li, L. & Fan, C.M. Nat. Med. 22, 889–896 (2016).

  9. 9

    Lukjanenko, L. et al. Nat. Med. 22, 897–905 (2016)

  10. 10

    Bentzinger, C.F. et al. Cell Stem Cell 12, 75–87 (2013).

Download references

Author information

Correspondence to Alessandra Sacco.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tierney, M., Sacco, A. The role of muscle stem cell–niche interactions during aging. Nat Med 22, 837–838 (2016). https://doi.org/10.1038/nm.4159

Download citation

Further reading