Two recent studies have shown that alterations in muscle stem cell–niche interactions during aging underlie the functional decline in regenerative potential. The reconstitution of this communication restores stem cell function and enhances skeletal muscle repair.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Marina Corral Spence/Nature Publishing Group
References
Chakkalakal, J.V., Jones, K.M., Basson, M.A. & Brack, A.S. Nature 490, 355–360 (2012).
Price, F.D. et al. Nat. Med. 20, 1174–1181 (2014).
Tierney, M.T. et al. Nat. Med. 20, 1182–1186 (2014).
Bernet, J.D. et al. Nat. Med. 20, 265–271 (2014).
Cosgrove, B.D. et al. Nat. Med. 20, 255–264 (2014).
García-Prat, L. et al. Nature 529, 37–42 (2016).
Sousa-Victor, P. et al. Nature 506, 316–321 (2014).
Rozo, M., Li, L. & Fan, C.M. Nat. Med. 22, 889–896 (2016).
Lukjanenko, L. et al. Nat. Med. 22, 897–905 (2016)
Bentzinger, C.F. et al. Cell Stem Cell 12, 75–87 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Tierney, M., Sacco, A. The role of muscle stem cell–niche interactions during aging. Nat Med 22, 837–838 (2016). https://doi.org/10.1038/nm.4159
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4159
