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Follicular T helper cells: hotspots for HIV-1 persistence

Reservoirs of virally infected cells that are resistant to standard antiretroviral therapy make HIV-1 infection an incurable disease. A new study shows that follicular T helper cells in lymph node germinal centers are prime niches for HIV-1 persistence during antiviral therapy.

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Figure 1: Lymph node CXCR5+PD-1+ follicular T helper (TFH) cells are sites of HIV-1 persistence during antiretroviral therapy.

Marina Corral Spence/Nature Publishing Group


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M.P. is supported by NIH grants AI110334 and AI104278. M.L. is supported by NIH grants AI106468, AI114235, AI117841, AI120008 and AI098487.

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Correspondence to Mathias Lichterfeld.

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The authors declare no competing financial interests.

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Paiardini, M., Lichterfeld, M. Follicular T helper cells: hotspots for HIV-1 persistence. Nat Med 22, 711–712 (2016).

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