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Targeting the brain as a cure for type 2 diabetes

Nature Medicine volume 22, pages 709–711 (2016)Cite this article

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A recent study has shown that a single dose of fibroblast growth factor (FGF) 1 into the central nervous system (CNS) of various mouse and rat models of type 2 diabetes results in profound and exceptionally long-lasting reductions in blood glucose. This work raises the possibility of truly revolutionary therapies for individuals with type 2 diabetes that target the brain FGF system.

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Figure 1: Scarlett et al. demonstrate that CNS administration of FGF1 in rodent models of diabetes type 2 causes sustained normalization of glucose levels (T2DM remission).

Marina Corral Spence/Nature Publishing Group

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Acknowledgements

D.A.S. has received research support from Novo Nordisk, Ethicon, Janssen and Boehringer Ingelheim. R.J.S. has received research support from Novo Nordisk, Ethicon, Janssen, Sanofi and Boehringer Ingelheim. R.J.S. has also served as a paid consultant for Novo Nordisk, Ethicon, Janssen, Novartis, Nestle, Daiichi Sankyo and Takeda.

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  1. Randy J. Seeley and Darleen A. Sandoval are in the Departments of Surgery, Internal Medicine and Nutritional Sciences at the University of Michigan, Ann Arbor, Michigan, USA.,

    Randy J Seeley & Darleen A Sandoval

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  1. Randy J Seeley
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  2. Darleen A Sandoval
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Correspondence to Randy J Seeley.

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Seeley, R., Sandoval, D. Targeting the brain as a cure for type 2 diabetes. Nat Med 22, 709–711 (2016). https://doi.org/10.1038/nm.4137

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