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Independence of epigenetic and genetic diversity in AML

A new study provides the first insights into epigenetic heterogeneity in AML. The study highlights a striking independence of genetic and epigenetic variation, and links the kinetics of epigenetic change to clinical outcome.

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Figure 1: Independence of epigenetic and genetic heterogeneity during the progression of AML.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Brian J P Huntly.

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Sasca, D., Huntly, B. Independence of epigenetic and genetic diversity in AML. Nat Med 22, 708–709 (2016). https://doi.org/10.1038/nm.4136

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