Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Independence of epigenetic and genetic diversity in AML

A new study provides the first insights into epigenetic heterogeneity in AML. The study highlights a striking independence of genetic and epigenetic variation, and links the kinetics of epigenetic change to clinical outcome.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Independence of epigenetic and genetic heterogeneity during the progression of AML.

Marina Corral Spence/Nature Publishing Group


  1. Greaves, M. Cancer Discov. 5, 806–820 (2015).

    Article  CAS  Google Scholar 

  2. Ley, T.J. et al. N. Engl. J. Med. 368, 2059–2074 (2013).

    Article  Google Scholar 

  3. Gawad, C., Koh, W. & Quake, S.R. Nat. Rev. Genet. 17, 175–188 (2016).

    Article  CAS  Google Scholar 

  4. Marusyk, A., Almendro, V. & Polyak, K. Nat. Rev. Cancer 12, 323–334 (2012).

    Article  CAS  Google Scholar 

  5. Grimwade, D., Ivey, A. & Huntly, B.J.P. Blood 127, 29–41 (2016).

    Article  CAS  Google Scholar 

  6. Figueroa, M.E. et al. Cancer Cell 17, 13–27 (2010).

    Article  CAS  Google Scholar 

  7. Li, S. et al. Nat. Med. 22, 792–799 (2016).

  8. Li, S. et al. Genome Biol. 15, 472 (2014).

    Article  Google Scholar 

  9. Pan, H. et al. Nat. Commun. 6, 6921 (2015).

    Article  CAS  Google Scholar 

  10. Mazor, T. et al. Cancer Cell 28, 307–317 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Brian J P Huntly.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sasca, D., Huntly, B. Independence of epigenetic and genetic diversity in AML. Nat Med 22, 708–709 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer