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From schizophrenia risk locus to schizophrenia genes

Nature Medicine volume 22, pages 583–584 (2016)Cite this article

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A new study in humans links genetic variants associated with schizophrenia to changes in the expression of two genes, arsenite methyltransferase (AS3MT) and BLOC-1 related complex subunit 7 (BORCS7). Subsequent investigations provide compelling evidence that AS3MT is involved in the etiology of schizophrenia.

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Figure 1: Understanding a locus associated with schizophrenia.

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Authors and Affiliations

  1. Children's Hospital of Philadelphia and the Division of Human Genetics, Department of Pediatrics, Patrick Sleiman and Hakon Hakonarson are at the Center for Applied Genomics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.,

    Patrick Sleiman & Hakon Hakonarson

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  1. Patrick Sleiman
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  2. Hakon Hakonarson
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Correspondence to Hakon Hakonarson.

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The authors declare no competing financial interests.

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Sleiman, P., Hakonarson, H. From schizophrenia risk locus to schizophrenia genes. Nat Med 22, 583–584 (2016). https://doi.org/10.1038/nm.4122

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