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Regulating inflammation with microbial metabolites

Nature Medicine volume 22, pages 581583 (2016) | Download Citation

Two new studies in mice show that the gut microbiota produces metabolites from dietary tryptophan that regulate inflammation in the gut and central nervous system.

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References

  1. 1.

    & Nat. Rev. Immunol. 4, 478–485 (2004).

  2. 2.

    et al. Sci. Transl. Med. 1, 6ra14 (2009).

  3. 3.

    et al. Nat. Med. 20, 159–166 (2014).

  4. 4.

    et al. Cell Host Microbe 14, 571–581 (2013).

  5. 5.

    et al. Nat. Med. 22, 598–605 (2016).

  6. 6.

    et al. Nat. Med. 22, 586–597 (2016).

  7. 7.

    et al. Nat. Genet. 43, 1066–1073 (2011).

  8. 8.

    et al. Immunity 29, 947–957 (2008).

  9. 9.

    et al. Nature 453, 106–109 (2008).

  10. 10.

    , , , & Behav. Brain Res. 277, 32–48 (2015).

  11. 11.

    et al. Cell 163, 1079–1094 (2015).

Download references

Acknowledgements

B.J.M. is supported by the Swiss National Science Foundation grant 310030-166210.

Author information

Affiliations

  1. Benjamin J. Marsland is at the Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

    • Benjamin J Marsland

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The author declares no competing financial interests.

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Correspondence to Benjamin J Marsland.

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DOI

https://doi.org/10.1038/nm.4117

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