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Regulation of pancreatic cancer aggressiveness by stromal stiffening

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive stromal component that hinders treatment. A new study shows how the genetic identity of pancreatic tumors might influence the physical properties of the associated stroma to promote tumor progression.

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Figure 1: Mechanosignaling of PDAC epithelial cells induces stromal remodeling.

Kim Caesar/Nature Publishing Group


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Correspondence to Michael F Olson.

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Rath, N., Olson, M. Regulation of pancreatic cancer aggressiveness by stromal stiffening. Nat Med 22, 462–463 (2016).

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