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Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status

Nature Medicine volume 22, pages 577578 (2016) | Download Citation

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This study was supported by INSERM grant EpiUM (M.-H.S., S.R.-R. and R.M.) and InCA grant UMCURE (M.-H.S. and S.R.-R.). The authors thank P.A. Van Der Velden (Leiden University) for kindly providing OMM1 and OMM2.5 cells.

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Author notes

    • Marie Schoumacher
    •  & Stéphanie Le Corre

    These authors contributed equally to this work.


  1. Institut Curie, Paris Sciences et Lettres Research University, Paris, France.

    • Marie Schoumacher
    • , Stéphanie Le Corre
    • , Alexandre Houy
    • , Eskeatnaf Mulugeta
    • , Marc-Henri Stern
    • , Sergio Roman-Roman
    •  & Raphaël Margueron
  2. Department of Translational Research, Paris, France.

    • Marie Schoumacher
    •  & Sergio Roman-Roman
  3. Institut National de la Santé et de la Recherche Médicale (INSERM) U934–Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 3215, Paris, France.

    • Stéphanie Le Corre
    • , Eskeatnaf Mulugeta
    •  & Raphaël Margueron
  4. INSERM U830, Paris, France.

    • Alexandre Houy
    •  & Marc-Henri Stern


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M.S. and S.L.C. performed experiments and prepared the figures; E.M. analyzed the ChIP-seq data; A.H. analyzed the transcriptomic data; M.S., M.-H.S., S.R.-R. and R.M. analyzed data and directed the study; M.S., S.R.-R. and R.M. wrote the manuscript; and all authors reviewed the manuscript and provided final approval for submission.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Raphaël Margueron.

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