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PTEN enables the development of pre-B acute lymphoblastic leukemia

Nature Medicine volume 22, pages 339–340 (2016)Cite this article

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Ablation of the tumor suppressor phosophatase and tensin homlog (PTEN) unexpectedly suppresses the development of pre-B acute lymphoblastic leukemia (ALL).

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Figure 1: B cell maturation and homeostasis depends on tightly regulated PI3K-AKT signaling.

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Authors and Affiliations

  1. Jérôme Fortin, Christian Bassi and Tak W. Mak are at the Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Canada.,

    Jérôme Fortin, Christian Bassi & Tak W Mak

  2. Tak W. Mak is also in the Department of Medical Biophysics, University of Toronto, University Health Network, Toronto, Canada, and the Ontario Cancer Institute, University Health Network, Toronto, Canada.,

    Tak W Mak

Authors
  1. Jérôme Fortin
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  2. Christian Bassi
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  3. Tak W Mak
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Corresponding author

Correspondence to Tak W Mak.

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The authors declare no competing financial interests.

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Fortin, J., Bassi, C. & Mak, T. PTEN enables the development of pre-B acute lymphoblastic leukemia. Nat Med 22, 339–340 (2016). https://doi.org/10.1038/nm.4083

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