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The cellular origins of drug resistance in cancer


Two new studies show that mechanisms of acquired resistance to targeted therapy in lung cancer do not necessarily pre-exist in resistant subclones. Instead, some cancers may harbor the potential to acquire a variety of drug-resistance mechanisms after response to targeted therapy.

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Figure 1: Differing biologies of acquired drug resistance.

Marina Corral Spence/Nature Publishing Group


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Correspondence to Geoffrey R Oxnard.

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Competing interests

G.R.O. has received consulting fees from Ariad, AstraZeneca, Boehringer-Ingehleim, Clovis and Genentech.

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Oxnard, G. The cellular origins of drug resistance in cancer. Nat Med 22, 232–234 (2016).

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