Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Tau toxicity feeds forward in frontotemporal dementia

A new study shows that aggregated forms of tau that cause frontotemporal dementia impair proteasome activity. Furthermore, proteasome inhibition can be alleviated by a small molecule that leads to proteasome phosphorylation and activation, thereby reducing tau accumulation.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Tau blocks the proteasome to increase tau accumulation.

Marina Corral Spence/Nature Publishing Group


  1. Spillantini, M.G. & Goedert, M. Lancet Neurol. 12, 609–622 (2013).

    CAS  Article  Google Scholar 

  2. Lee, M.J., Lee, J.H. & Rubinsztein, D.C. Prog. Neurobiol. 105, 49–59 (2013).

    CAS  Article  Google Scholar 

  3. Myeku, N. et al. Nat. Med. 22, 46–53 (2016).

    CAS  Article  Google Scholar 

  4. Goldberg, A.L. Biochem. Soc. Trans. 35, 12–17 (2007).

    CAS  Article  Google Scholar 

  5. Asai, M. et al. J. Mol. Cell. Cardiol. 46, 452–462 (2009).

    CAS  Article  Google Scholar 

  6. Zhang, F. et al. J. Biol. Chem. 282, 22460–22471 (2007).

    CAS  Article  Google Scholar 

  7. Myeku, N., Wang, H. & Figueiredo-Pereira, M.E. Neurosci. Lett. 527, 126–131 (2012).

    CAS  Article  Google Scholar 

  8. Deriziotis, P. et al. EMBO J. 30, 3065–3077 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to David C Rubinsztein.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rubinsztein, D. Tau toxicity feeds forward in frontotemporal dementia. Nat Med 22, 24–25 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing