Targeting a regulator of protein homeostasis in myeloproliferative neoplasms

A new study demonstrates that dysregulation of proteostasis can be a transforming event in hematopoiesis that could prove to be therapeutically actionable for treatment of myeloproliferative neoplasms.

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Figure 1: Deletion of Zfand2b in mice results in a myeloproliferative disorder.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Ross L Levine.

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The authors declare no competing financial interests.

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LaFave, L., Levine, R. Targeting a regulator of protein homeostasis in myeloproliferative neoplasms. Nat Med 22, 20–21 (2016). https://doi.org/10.1038/nm.4028

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