Illuminating inflammasome activity in vivo

Sentinel macrophages in the lymph node provide a first line of defense against invading viruses. A new study visualizes inflammasome activation in virally infected nodal macrophages in mice and shows that this activation augments both innate and adaptive immunity.

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Figure 1: Inflammasome activation in SCS macrophages enhances innate and adaptive immunity.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Heather D Hickman.

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Hickman, H. Illuminating inflammasome activity in vivo. Nat Med 22, 22–23 (2016). https://doi.org/10.1038/nm.4026

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