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Translational strategies in aging and age-related disease

Nature Medicine volume 21, pages 1395–1399 (2015)Cite this article

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Abstract

Aging is a risk factor for several of the world's most prevalent diseases, including neurodegenerative disorders, cancer, cardiovascular disease and metabolic disease. Although our understanding of the molecular pathways that contribute to the aging process and age-related disease is progressing through the use of model organisms, how to apply this knowledge in the clinic is less clear. In September, Nature Medicine, in collaboration with the Volkswagen Foundation, hosted a conference at the beautiful Herrenhausen Palace in Hannover, Germany with the goal of broadening our understanding of the aging process and its meaning as a 'risk factor' in disease. Here, several of the speakers at that conference answer questions posed by Nature Medicine.

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Author information

Author notes

  1. The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, California, USA.

Authors and Affiliations

  1. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Mary Armanios

  2. Translational Gerontology Branch, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, USA

    Rafael de Cabo

  3. Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA

    Joan Mannick

  4. Department of Genetics, Institute of Healthy Ageing, Evolution, and Environment, University College London, London, UK

    Linda Partridge

  5. Max Planck Institute for Biology of Ageing, Cologne, Germany

    Jan van Deursen

  6. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA

    Jan van Deursen

  7. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA

    Saul Villeda

  8. Department of Anatomy, University of California, San Francisco, San Francisco, California, USA

    Saul Villeda

Authors
  1. Mary Armanios
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  2. Rafael de Cabo
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  3. Joan Mannick
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  4. Linda Partridge
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  5. Jan van Deursen
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  6. Saul Villeda
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Competing interests

J.M. declares an equity interest in Novartis. All other authors declare no competing financial interests.

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Armanios, M., de Cabo, R., Mannick, J. et al. Translational strategies in aging and age-related disease. Nat Med 21, 1395–1399 (2015). https://doi.org/10.1038/nm.4004

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