Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Translational strategies in aging and age-related disease


Aging is a risk factor for several of the world's most prevalent diseases, including neurodegenerative disorders, cancer, cardiovascular disease and metabolic disease. Although our understanding of the molecular pathways that contribute to the aging process and age-related disease is progressing through the use of model organisms, how to apply this knowledge in the clinic is less clear. In September, Nature Medicine, in collaboration with the Volkswagen Foundation, hosted a conference at the beautiful Herrenhausen Palace in Hannover, Germany with the goal of broadening our understanding of the aging process and its meaning as a 'risk factor' in disease. Here, several of the speakers at that conference answer questions posed by Nature Medicine.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Longo, V.D. et al. Aging Cell 14, 497–510 (2015).

    Article  CAS  Google Scholar 

  2. Fabbri, E. et al. J. Am. Med. Dir. Assoc. 16, 640–647 (2015).

    Article  Google Scholar 

  3. Richardson, A. et al. J. Gerontol. A Biol. Sci. Med. Sci. (2015).

  4. Monk, T.G. & Price, C.C. Curr. Opin. Crit. Care 17, 376–381 (2011).

    Article  Google Scholar 

  5. The National Coalition for Cancer Survivorship. Pazdur: “The primary endpoint of every trial should be the patient.” The Cancer Letter (23 October 2015)

  6. Stanley, S.E. & Armanios, M. Curr. Opin. Genet. Dev. 33, 1–9 (2015).

    Article  CAS  Google Scholar 

  7. Kennedy, B.K. et al. Cell 159, 709–713 (2014).

    Article  CAS  Google Scholar 

  8. Burch, J.B. et al. J. Gerontol. A Biol. Sci. Med. Sci. 69 Suppl 1, S1–S3 (2014).

    Article  Google Scholar 

  9. Fontana, L. et al. Nature 511, 405–407 (2014).

    Article  CAS  Google Scholar 

  10. Sperling, R.A., Jack, C.R., Jr. & Aisen, P.S. Sci. Transl. Med. 3, 111cm133 (2011).

    Article  Google Scholar 

  11. Avorn, J. & Kesselheim, A.S. N. Engl. J. Med. 372, 2473–2475 (2015).

    Article  CAS  Google Scholar 

  12. Doody, R.S. et al. N. Engl. J. Med. 370, 311–321 (2014).

    Article  CAS  Google Scholar 

  13. Belsky, D.W. et al. Proc. Natl. Acad. Sci. USA 112, E4104–E4110 (2015).

    Article  CAS  Google Scholar 

  14. Verghese, J. et al. J. Neurol. Neurosurg. Psychiatry 78, 929–935 (2007).

    Article  Google Scholar 

  15. Kaeberlein, M. Vet Pathol. doi:10.1177/0300985815591082 (15 June 2015).

  16. Fontana, L. et al. Am. J. Physiol. Endocrinol. Metab. 293, E197–E202 (2007).

    Article  CAS  Google Scholar 

  17. Brunner, S., Herndler-Brandstetter, D., Weinberger, B. & Grubeck-Loebenstein, B. Ageing Res. Rev. 10, 362–369 (2011).

    Article  CAS  Google Scholar 

  18. Friedman, D.B. & Johnson, T.E. Genetics 118, 75–86 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M.N. & Madeo, F. Cell 157, 1515–1526 (2014).

    Article  CAS  Google Scholar 

  20. Ingram, D.K. et al. Aging Cell 5, 97–108 (2006).

    Article  CAS  Google Scholar 

  21. Madeo, F., Pietrocola, F., Eisenberg, T. & Kroemer, G. Nat. Rev. Drug Discov. 13, 727–740 (2014).

    Article  CAS  Google Scholar 

  22. Jonker, M.J. et al. Aging Cell 12, 901–909 (2013).

    Article  CAS  Google Scholar 

  23. Liao, C.Y., Rikke, B.A., Johnson, T.E., Diaz, V. & Nelson, J.F. Aging Cell 9, 92–95 (2010).

    Article  CAS  Google Scholar 

  24. Mannick J.B. et al. Sci. Transl. Med. 24, 268ra179 (2014).

    Article  Google Scholar 

  25. Sadagurski, M. et al. Am. J. Physiol. Endocrinol. Metab. 306, E1305–E1314 (2014).

    Article  CAS  Google Scholar 

  26. Villeda, S.A. et al. Nature 477, 90–94 (2011).

    Article  CAS  Google Scholar 

  27. Katsimpardi, L. et al. Science 344, 630–634 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Ethics declarations

Competing interests

J.M. declares an equity interest in Novartis. All other authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Armanios, M., de Cabo, R., Mannick, J. et al. Translational strategies in aging and age-related disease. Nat Med 21, 1395–1399 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing