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A TGF-β pathway associated with cancer cachexia

Nature Medicine volume 21, pages 1248–1249 (2015)Cite this article

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Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.

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Figure 1: Bone metastasis leads to skeletal muscle weakness.

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Authors and Affiliations

  1. Denis C. Guttridge is in the Department of Molecular Virology, Immunology and Medical Genetics, Arthur G. James Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio, USA.,

    Denis C Guttridge

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  1. Denis C Guttridge
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Correspondence to Denis C Guttridge.

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Guttridge, D. A TGF-β pathway associated with cancer cachexia. Nat Med 21, 1248–1249 (2015). https://doi.org/10.1038/nm.3988

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