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Targeting Toll-like receptors to treat chronic pain

Chronic pain affects millions of people worldwide. A new study presents a promising therapeutic strategy in which Toll-like receptor (TLR) 5 stimulation enables the analgesic compound, QX-314, to specifically enter and silence large fiber sensory neurons, which convey pain in the setting of injury.

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Figure 1: A strategy to treat persistent mechanical pain.

Katie Vicari/Nature Publishing Group

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Acknowledgements

Funding was provided by US National Institutes of Health NS084191, the Rita Allen Foundation and the American Pain Society to R.P.S.

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Correspondence to Rebecca P Seal.

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Peirs, C., Seal, R. Targeting Toll-like receptors to treat chronic pain. Nat Med 21, 1251–1252 (2015). https://doi.org/10.1038/nm.3986

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