Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Metabolic labeling puts the microbiome under the microscope

Seven years after the launch of the Human Microbiome Project, we still lack sufficient tools to visualize the microbiome in a living host. A new study provides experimental tools to label and track live anaerobic bacteria in the microbial communities in the mouse gut and beyond.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Geva-Zatorsky et al.6 developed a general strategy to label anaerobic microbes for real-time imaging of microbial communities.

References

  1. Faith, J.J. et al. Science 341, 1237439 (2013).

    Article  Google Scholar 

  2. Gevers, D. et al. Cell Host Microbe 15, 382–392 (2014).

    Article  CAS  Google Scholar 

  3. Qin, J. et al. Nature 464, 59–65 (2010).

    Article  CAS  Google Scholar 

  4. Yatsunenko, T. et al. Nature 486, 222–227 (2012).

    Article  CAS  Google Scholar 

  5. Valm, A.M. et al. Proc. Natl. Acad. Sci. USA 108, 4152–4157 (2011).

    Article  CAS  Google Scholar 

  6. Geva-Zatorsky, N. et al. Nat. Med. 21, 1091–1100 (2015).

    Article  CAS  Google Scholar 

  7. Boyce, M. & Bertozzi, C.R. Nat. Meth. 8, 638–642 (2011).

    Article  CAS  Google Scholar 

  8. Surana, N.K. & Kasper, D.L. Immunol. Rev. 245, 13–26 (2012).

    Article  CAS  Google Scholar 

  9. Wexler, H.M. Clin. Microbiol. Rev. 20, 593–621 (2007).

    Article  CAS  Google Scholar 

  10. Radajewski, S. et al. Nature 403, 646–649 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeremiah J Faith.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Britton, G., Faith, J. Metabolic labeling puts the microbiome under the microscope. Nat Med 21, 977–978 (2015). https://doi.org/10.1038/nm.3941

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3941

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing