Aging is a major risk factor for cognitive decline and neurodegenerative diseases. A new study identified β2-microglobulin as a blood-borne factor that detrimentally influences the brain during the aging process.
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References
Smith, L.K. et al. Nat. Med. 21, 932–937 (2015).
Villeda, S.A. et al. Nat. Med. 20, 659–663 (2014).
Bert, P. J. Anatomie Physiologie. 1, 69–87 (1864).
Villeda, S.A. et al. Nature 477, 90–94 (2011).
Bochner, D.N. et al. Sci. Transl. Med. 6, 258ra140 (2014).
Djurisic, M. et al. Proc. Natl. Acad. Sci. USA 110, 20771–20776 (2013).
Montagne, A. et al. Neuron 85, 296–302 (2015).
Filiano, A.J., Gadani, S.P. & Kipnis, J. Brain Res. 1617, 18–27 (2015).
Quan, N. & Banks, W.A. Brain Behav. Immun. 21, 727–735 (2007).
Kunis, G. et al. Brain 136, 3427–3440 (2013).
Iliff, J.J. et al. Sci. Transl. Med. 4, 147ra111 (2012).
Louveau, A. et al. Nature 523, 337–341 (2015).
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Filiano, A., Kipnis, J. Breaking bad blood: β2-microglobulin as a pro-aging factor in blood. Nat Med 21, 844–845 (2015). https://doi.org/10.1038/nm.3926
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DOI: https://doi.org/10.1038/nm.3926
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