Progenitor cell engraftment in the lung: at last?

Article metrics

Engraftment of progenitor cells to effect repair of injured lungs has been a major challenge. A new study combines a conditioning strategy adopted from bone marrow transplantation with a lung injury model to bring this potential therapeutic approach closer to reality.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Engraftment of lung progenitors.

Debbie Maizels/Nature Publishing Group

References

  1. 1

    Stripp, B., Hogan, B. & Thannickal, V. Nat. Med. 17, 788–789 (2011).

  2. 2

    Lewis, D.R., Clegg, L.X. & Johnson, N.J. Int. J. Tuberc. Lung Dis. 13, 1008–1014 (2009).

  3. 3

    McCurry, K.R. et al. Am. J. Transplant. 9, 942–958 (2009).

  4. 4

    Rosen, C. et al. Nat. Med. 20, 869–879 (2015).

  5. 5

    Jagannathan-Bogdan, M. & Zon, L.I. Development 140, 2463–2467 (2013).

  6. 6

    Rawlins, E.L., Ostrowski, L.E., Randell, S.H. & Hogan, B.L. Proc. Natl. Acad. Sci. USA 104, 410–417 (2007).

  7. 7

    Hogan, B.L. et al. Cell Stem Cell 15, 123–138 (2014).

  8. 8

    Vaughan, A.E. et al. Nature 517, 621–625 (2015).

  9. 9

    Morrisey, E.E. & Hogan, B.L. Dev. Cell 18, 8–23 (2010).

  10. 10

    Kajstura, J. et al. N. Engl. J. Med. 364, 1795–1806 (2011).

  11. 11

    Wansleeben, C., Barkauskas, C.E., Rock, J.R. & Hogan, B.L. Dev. Biol. 2, 131–148 (2013).

  12. 12

    Giangreco, A., Reynolds, S.D. & Stripp, B.R. Am. J. Pathol. 161, 173–182 (2002).

  13. 13

    Rock, J.R. et al. Proc. Natl. Acad. Sci. USA 106, 12771–12775 (2009).

Download references

Author information

Correspondence to Hans-Willem Snoeck.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Snoeck, H. Progenitor cell engraftment in the lung: at last?. Nat Med 21, 842–844 (2015) doi:10.1038/nm.3923

Download citation

Further reading