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Supporting itch: a new role for astrocytes in chronic itch

Nature Medicine volume 21, pages 841842 (2015) | Download Citation

A new study shows that astrocytes are involved in the development of chronic itch in a mouse model. This is dependent on upregulation of lipocalin 2 (LCN2) by the transcription factor STAT-3 and astrogliosis.

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Author information

Affiliations

  1. Dustin Green is in the Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Department of Dermatology and Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

    • Dustin Green
  2. Xinzhong Dong is in the Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology and the Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

    • Xinzhong Dong

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Dustin Green or Xinzhong Dong.

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DOI

https://doi.org/10.1038/nm.3921

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