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Germs and joints: the contribution of the human microbiome to rheumatoid arthritis

Nature Medicine volume 21, pages 839–841 (2015)Cite this article

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Rheumatoid arthritis (RA) is a debilitating autoimmune disorder, the etiology of which is poorly understood. A new study reveals dysbiosis in gut and oral microbiomes of affected individuals, potentially providing a basis for patient stratification and clues to pathophysiological mechanisms of RA onset and progression.

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Figure 1: The potential influence of the human microbiome on rheumatoid arthritis.

References

  1. Brusca, S.B., Abramson, S.B. & Scher, J.U. Curr. Opin. Rheumatol. 26, 101–107 (2014).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Scher, J.U. et al. eLife 2, e01202 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Zhang, X. et al. Nat. Med. 21, 895–905 (2015).

    Article  CAS  PubMed  Google Scholar 

  4. Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).

  5. MacGregor, A.J. et al. Arthritis Rheum. 43, 30–37 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Rosenstein, E.D., Greenwald, R.A., Kushner, L.J. & Weissmann, G. Inflamm. 28, 311–318 (2004).

    Article  Google Scholar 

  7. Konig, M.F., Paracha, A.S., Moni, M., Bingham, C.O. III & Andrade, F. Ann. Rheum. Dis. doi:10.1136/annrheumdis-2014–205385 (26 May 2014).

  8. Kamphuis, S. et al. Lancet 366, 50–56 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. Kverka, M. & Tlaskalova-Hogenova, H. APMIS 121, 403–421 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Sonnenburg, J.L. Nature 518, S10 (2015).

    Article  CAS  PubMed  Google Scholar 

  11. Devaraj, S., Hemarajata, P. & Versalovic, J. Clin. Chem. 59, 617–628 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Hedin, C. et al. Gut doi:10.1136/gutjnl-2014–308896 (8 April 2015).

  13. Halaris, A. Curr. Psychiatry Rep. 15, 400 (2013).

    Article  PubMed  Google Scholar 

Download references

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  1. Geraint B. Rogers is in the Infection & Immunity Theme of the South Australian Health and Medical Research Institute, and is based at the School of Medicine, Flinders University, Adelaide, Australia.,

    Geraint B Rogers

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  1. Geraint B Rogers
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Correspondence to Geraint B Rogers.

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Rogers, G. Germs and joints: the contribution of the human microbiome to rheumatoid arthritis. Nat Med 21, 839–841 (2015). https://doi.org/10.1038/nm.3916

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