A gut feeling about immunity

As it becomes evident that the microbiome exerts an influence on the human immune system, scientists have begun to ponder therapies that might act on intestinal microbes to reduce harmful inflammation. Roxanne Khamsi reports.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Brestoff, J.R. & Artis, D. Nat Immunol. 14, 676–684 (2013).

  2. 2

    Trompette, A. et al. Nat. Med. 20, 159–166 (2014).

  3. 3

    Scheppach, W. et al. Gastroenterology 103, 51–56 (1992).

  4. 4

    O'Keefe, S.J.D. et al. Nat. Commun. 6, 6342 (2015).

  5. 5

    Wall, R., Ross, R.P., Fitzgerald, G.F. & Stanton, C. Nutr. Rev. 68, 280–289 (2010).

  6. 6

    Liou, A.P. et al. Sci. Trans. Med. 5, doi: 10.1126/scitranslmed.3005687 (2013).

  7. 7

    Arribas, B. et al. Br. J. Pharmacol. 157, 1024–1033 (2009).

  8. 8

    Becker, H.M., Apladas, A., Scharl, M., Fried, M. & Rogler, G. Digestion 82, 110–118 (2014).

  9. 9

    Atarashi, K. et al. Nature 500, 232–236 (2013).

  10. 10

    Tang, W.H. et al. J. Card. Fail. 21, 91–96 (2015).

  11. 11

    Wang, Z. et al. Nature 472, 57–63 (2011).

  12. 12

    Gregory, J.C. et al. J. Biol. Chem. 290, 5647–5660 (2015).

  13. 13

    Scorletti, E. et al. Hepatology 60, 1211–1221 (2014).

  14. 14

    Lukens, J.R. et al. Nature 516, 246–249 (2014).

  15. 15

    Trompette, A. et al. Nat. Med. 20, 159–166 (2014).

  16. 16

    Vieira, A.T. et al. Arthritis Rheumatol. 67, 1646–1656 (2015).

  17. 17

    You, J., Dong, H., Mann, E.R., Knight, S.C. & Yaqoob, P. Immunobiology 219, 138–148 (2014).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Khamsi, R. A gut feeling about immunity. Nat Med 21, 674–676 (2015). https://doi.org/10.1038/nm.3906

Download citation

Further reading