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Liquid biopsies reveal the dynamic nature of resistance mechanisms in solid tumors

Two new studies demonstrate that so-called 'liquid biopsies' may reveal important genomic information needed to monitor treatment responses, forecast tumor recurrences, and provide a rationale for novel therapeutic strategies in patients with lung cancer and colon cancer.

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Figure 1: Longitudinal monitoring of cfDNA in a patient with a solid tumor.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Christine M Lovly.

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Competing interests

C.M.L. has served as a consultant for Pfizer, Novartis, and Sequenom and has been an invited speaker for Abbott and Qiagen. C.M.L. has received research support from AstraZeneca and Novartis.

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Meador, C., Lovly, C. Liquid biopsies reveal the dynamic nature of resistance mechanisms in solid tumors. Nat Med 21, 663–665 (2015). https://doi.org/10.1038/nm.3899

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