Two new studies demonstrate that so-called 'liquid biopsies' may reveal important genomic information needed to monitor treatment responses, forecast tumor recurrences, and provide a rationale for novel therapeutic strategies in patients with lung cancer and colon cancer.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Microfluidic enrichment for the single cell analysis of circulating tumor cells
Scientific Reports Open Access 29 February 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gerlinger, M. et al. N. Engl. J. Med. 366, 883–892 (2012).
Yap, T.A., Gerlinger, M., Futreal, P.A., Pusztai, L. & Swanton, C. Sci. Transl. Med. 4, 127ps110 (2012).
Thress, K.S. et al. Nat. Med. 21, 560–562 (2015).
Siravegna, G. et al. Nat. Med. 21, 795–801 (2015).
Yu, H.A., Riely, G.J. & Lovly, C.M. Clin. Cancer Res. 20, 5898–5907 (2014).
Sequist, L.V. et al. Sci. Transl. Med. 3, 75ra26 (2011).
Cross, D.A. et al. Cancer Discov. 4, 1046 (2014).
Jänne, P.A. et al. N. Engl. J. Med. 372, 1689–1699 (2015).
Misale, S., Di Nicolantonio, F., Sartore-Bianchi, A., Siena, S. & Bardelli, A. Cancer Discov. 4, 1269–1280 (2014).
Misale, S. et al. Nature 486, 532–536 (2012).
Piotrowska, Z. et al. Cancer Discov. 10.1158/2159-8290.CD-15-0399 (2015).
Krebs, M.G. et al. Nat. Rev. Clin. Oncol. 11, 129–144 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
C.M.L. has served as a consultant for Pfizer, Novartis, and Sequenom and has been an invited speaker for Abbott and Qiagen. C.M.L. has received research support from AstraZeneca and Novartis.
Rights and permissions
About this article
Cite this article
Meador, C., Lovly, C. Liquid biopsies reveal the dynamic nature of resistance mechanisms in solid tumors. Nat Med 21, 663–665 (2015). https://doi.org/10.1038/nm.3899
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3899
This article is cited by
-
Microfluidic enrichment for the single cell analysis of circulating tumor cells
Scientific Reports (2016)
-
Pathologists and liquid biopsies: to be or not to be?
Virchows Archiv (2016)