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Shifts in macrophage cytokine production drive muscle fibrosis

Muscle fibrosis after acute injury can be debilitating, but in chronic muscle disease it can be lethal. A new study reveals that shifts in macrophage phenotype in injured or diseased muscle can influence whether connective tissue production by fibro/adipogenic precursors in muscle is beneficial or pathological.

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Figure 1: Acute muscle injury leads to FAP proliferation and muscle invasion by myeloid cells.

Marina Corral Spence/Nature Publishing Group


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Correspondence to James G Tidball.

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Tidball, J., Wehling-Henricks, M. Shifts in macrophage cytokine production drive muscle fibrosis. Nat Med 21, 665–666 (2015).

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