Shifts in macrophage cytokine production drive muscle fibrosis

Muscle fibrosis after acute injury can be debilitating, but in chronic muscle disease it can be lethal. A new study reveals that shifts in macrophage phenotype in injured or diseased muscle can influence whether connective tissue production by fibro/adipogenic precursors in muscle is beneficial or pathological.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Acute muscle injury leads to FAP proliferation and muscle invasion by myeloid cells.

Marina Corral Spence/Nature Publishing Group

References

  1. 1

    Joe, A.W. et al. Nat. Cell Biol. 12, 153–163 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S. & Tsuchida, K. Nat. Cell Biol. 12, 143–152 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Tidball, J.G., Dorshkind, K. & Wehling-Henricks, M. Development 141, 1184–1196 (2014).

    CAS  Article  Google Scholar 

  4. 4

    Finsterer, J. & Stollberger, C. Cardiology 99, 1–19 (2003).

    Article  Google Scholar 

  5. 5

    Forst, J. & Forst, R. Neuromuscul. Disord. 9, 176–181 (1999).

    CAS  Article  Google Scholar 

  6. 6

    Vidal, B. et al. Genes Dev. 22, 1747–1752 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Wehling-Henricks, M. et al. PLoS ONE 5, e10763 (2010).

    Article  Google Scholar 

  8. 8

    Lemos, D.R. et al. Nat. Med. 21, 786–794 (2015).

    CAS  Article  Google Scholar 

  9. 9

    Akhmetshina, A. et al. FASEB J. 22, 2214–2222 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Campbell, J. et al. J. Immunol. 173, 6928–6937 (2004).

    CAS  Article  Google Scholar 

  11. 11

    Manley, P.W. et al. Biochim. Biophys. Acta 1804, 445–453 (2010).

    CAS  Article  Google Scholar 

  12. 12

    Deng, B., Wehling-Henricks, M., Villalta, S.A., Wang, Y. & Tidball, J.G. J. Immunol. 189, 3669–3680 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to James G Tidball.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tidball, J., Wehling-Henricks, M. Shifts in macrophage cytokine production drive muscle fibrosis. Nat Med 21, 665–666 (2015). https://doi.org/10.1038/nm.3896

Download citation

Further reading