Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Shifts in macrophage cytokine production drive muscle fibrosis

Muscle fibrosis after acute injury can be debilitating, but in chronic muscle disease it can be lethal. A new study reveals that shifts in macrophage phenotype in injured or diseased muscle can influence whether connective tissue production by fibro/adipogenic precursors in muscle is beneficial or pathological.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Acute muscle injury leads to FAP proliferation and muscle invasion by myeloid cells.

Marina Corral Spence/Nature Publishing Group


  1. 1

    Joe, A.W. et al. Nat. Cell Biol. 12, 153–163 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S. & Tsuchida, K. Nat. Cell Biol. 12, 143–152 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Tidball, J.G., Dorshkind, K. & Wehling-Henricks, M. Development 141, 1184–1196 (2014).

    CAS  Article  Google Scholar 

  4. 4

    Finsterer, J. & Stollberger, C. Cardiology 99, 1–19 (2003).

    Article  Google Scholar 

  5. 5

    Forst, J. & Forst, R. Neuromuscul. Disord. 9, 176–181 (1999).

    CAS  Article  Google Scholar 

  6. 6

    Vidal, B. et al. Genes Dev. 22, 1747–1752 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Wehling-Henricks, M. et al. PLoS ONE 5, e10763 (2010).

    Article  Google Scholar 

  8. 8

    Lemos, D.R. et al. Nat. Med. 21, 786–794 (2015).

    CAS  Article  Google Scholar 

  9. 9

    Akhmetshina, A. et al. FASEB J. 22, 2214–2222 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Campbell, J. et al. J. Immunol. 173, 6928–6937 (2004).

    CAS  Article  Google Scholar 

  11. 11

    Manley, P.W. et al. Biochim. Biophys. Acta 1804, 445–453 (2010).

    CAS  Article  Google Scholar 

  12. 12

    Deng, B., Wehling-Henricks, M., Villalta, S.A., Wang, Y. & Tidball, J.G. J. Immunol. 189, 3669–3680 (2012).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to James G Tidball.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tidball, J., Wehling-Henricks, M. Shifts in macrophage cytokine production drive muscle fibrosis. Nat Med 21, 665–666 (2015).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing