Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia

A new study identifies recurrent mutations in the purine biosynthesis gene phosphoribosyl pyrophosphate synthetase 1 (PRPS1) in relapsed acute lymphoblastic leukemia (ALL). This work highlights the importance of this pathway in the pathogenesis of relapse and suggests an approach to predicting and circumventing resistance in ALL.

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Figure 1: The role of PRPS1 mutations in the pathogenesis of relapse in ALL.

Kim Caesar/Nature Publishing Group

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Correspondence to Charles G Mullighan.

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Mullighan, C. Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia. Nat Med 21, 553–554 (2015). https://doi.org/10.1038/nm.3876

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