Unpleasant memories: tissue-embedded T cell memory drives skin hypersensitivity

Tissue-resident memory T cells (TRM cells) protect against recurrent or renewed infection in barrier tissues such as skin and mucosa. A new study sheds light on the clonal origin of TRM cells and demonstrates a crucial role for tissue-embedded T cell memory in contact hypersensitivity in skin.

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Figure 1: TRM and recirculating memory T cells are derived from the same precursors.

Kim Caesar/Nature Publishing Group

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Correspondence to Thomas Gebhardt.

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Gebhardt, T., Carbone, F. Unpleasant memories: tissue-embedded T cell memory drives skin hypersensitivity. Nat Med 21, 551–552 (2015). https://doi.org/10.1038/nm.3874

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