The maintenance of blood glucose involves the coordination of multiple organ systems. Two new studies indicate that metformin and resveratrol activate metabolic sensors in the duodenum and initiate a neural loop that reduces liver glucose production in rat models of type 2 diabetes.
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The authors declare no competing financial interests.
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Smith, B., Steinberg, G. Duodenal energy sensing regulates hepatic glucose output. Nat Med 21, 428–429 (2015). https://doi.org/10.1038/nm.3859