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Duodenal energy sensing regulates hepatic glucose output

The maintenance of blood glucose involves the coordination of multiple organ systems. Two new studies indicate that metformin and resveratrol activate metabolic sensors in the duodenum and initiate a neural loop that reduces liver glucose production in rat models of type 2 diabetes.

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Figure 1: Proposed mechanism by which metformin and resveratrol lower hepatic glucose output.

Kim Caesar/Nature Publishing Group


  1. Duca, F.A. et al. Nat. Med. 21, 506–511 (2015).

    Article  CAS  Google Scholar 

  2. Cote, C.D. et al. Nat. Med. 21, 498–505 (2015).

    Article  CAS  Google Scholar 

  3. O'Neill, H.M., Holloway, G.P. & Steinberg, G.R. Mol. Cell. Endocrinol. 366, 135–151 (2013).

    Article  CAS  Google Scholar 

  4. Nogueiras, R. et al. Physiol. Rev. 92, 1479–1514 (2012).

    Article  CAS  Google Scholar 

  5. He, L. & Wondisford, F.E. Cell Metab. 21, 159–162 (2015).

    Article  CAS  Google Scholar 

  6. Natali, A. & Ferrannini, E. Diabetologia 49, 434–441 (2006).

    Article  CAS  Google Scholar 

  7. Fullerton, M.D. et al. Nat. Med. 19, 1649–1654 (2013).

    Article  CAS  Google Scholar 

  8. Foretz, M. et al. J. Clin. Invest. 120, 2355–2369 (2010).

    Article  CAS  Google Scholar 

  9. Miller, R.A. et al. Nature 494, 256–260 (2013).

    Article  CAS  Google Scholar 

  10. Baur, J.A. et al. Nature 444, 337–342 (2006).

    Article  CAS  Google Scholar 

  11. Liu, K., Zhou, R., Wang, B. & Mi, M.T. Am. J. Clin. Nutr. 99, 1510–1519 (2014).

    Article  CAS  Google Scholar 

  12. Um, J.H. et al. Diabetes 59, 554–563 (2010).

    Article  CAS  Google Scholar 

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Correspondence to Gregory R Steinberg.

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Smith, B., Steinberg, G. Duodenal energy sensing regulates hepatic glucose output. Nat Med 21, 428–429 (2015).

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