To target and kill cancer cells, oncolytic viruses exploit signaling pathways that promote tumor growth. A new study shows that the cancer stromal fibroblast factor FGF2 is a crucial component of a tumor–TGF-β axis that renders cancer cells sensitive to virus infection.
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Chiocca, E.A. & Rabkin, S.D. Cancer Immunol. Res. 2, 295–300 (2014).
Aghi, M.K. & Chiocca, E.A. Mol. Ther. 17, 8–9 (2009).
Markert, J.M. et al. Mol. Ther. 17, 199–207 (2009).
Ilkow, C.S. et al. Nat. Med. 21, 530–536 (2015).
Junttila, M.R. & de Sauvage, F.J. Nature 501, 346–354 (2013).
Kalluri, R. & Zeisberg, M. Nat. Rev. Cancer 6, 392–401 (2006).
Tripathi, M., Billet, S. & Bhowmick, N.A. Cell Adhes. Migr. 6, 231–235 (2012).
Finak, G. et al. Nat. Med. 14, 518–527 (2008).
Chiocca, E.A. Curr. Opin. Mol. Ther. 10, 38–45 (2008).
Alvarez-Breckenridge, C.A. et al. Nat. Med. 18, 1827–1834 (2012).
Workenhe, S.T. & Mossman, K.L. Mol. Ther. 22, 251–256 (2014).
McMillin, D.W., Negri, J.M. & Mitsiades, C.S. Nat. Rev. Drug Discov. 12, 217–228 (2013).
Kojima, Y. et al. Proc. Natl. Acad. Sci. USA 107, 20009–20014 (2010).
The authors declare no competing financial interests.
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Bronisz, A., Chiocca, E. A cross-talk network that facilitates tumor virotherapy. Nat Med 21, 426–427 (2015). https://doi.org/10.1038/nm.3857