To target and kill cancer cells, oncolytic viruses exploit signaling pathways that promote tumor growth. A new study shows that the cancer stromal fibroblast factor FGF2 is a crucial component of a tumor–TGF-β axis that renders cancer cells sensitive to virus infection.
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Bronisz, A., Chiocca, E. A cross-talk network that facilitates tumor virotherapy. Nat Med 21, 426–427 (2015). https://doi.org/10.1038/nm.3857
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DOI: https://doi.org/10.1038/nm.3857
