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Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

Type 2 diabetes occurs when the pancreatic beta cells fail to meet the increased insulin requirement in insulin-resistant individuals. A new therapeutic approach targeting glutamate receptors on beta cells improves insulin secretion and preserves beta cell mass.

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Figure 1: Dextrorphan actions and the regulation of insulin secretion.

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Correspondence to Claes B Wollheim or Pierre Maechler.

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Wollheim, C., Maechler, P. Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?. Nat Med 21, 310–311 (2015).

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