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Harnessing gene repression to inhibit leukemia

Developing therapeutics for cancers targeting driver mutations in epigenetic regulators is a challenging frontier in cancer therapy. A new study identifies a pathway that, when activated, inhibits the actions of the histone methyltransferase DOT1L in MLL fusion leukemia.

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Figure 1: MLL-AF9 fusion complexes as shown in blue and light blue activate transcription through the recruitment of the H3K79 methylase DOT1L.


  1. Li, B.E. & Ernst, P. Exp. Hematol. 42, 995–1012 (2014).

    Article  CAS  Google Scholar 

  2. Daigle, S.R. et al. Blood 122, 1017–1025 (2013).

    Article  CAS  Google Scholar 

  3. Chen, C.-W. et al. Nat. Med. 21, 335–343 (2015).

    Article  CAS  Google Scholar 

  4. Blander, G. & Guarente, L. Annu. Rev. Biochem. 73, 417–435 (2004).

    Article  CAS  Google Scholar 

  5. Martínez-Redondo, P. & Vaquero, A. Genes Cancer 4, 148–163 (2013).

    Article  Google Scholar 

  6. Vaquero, A. et al. Nature 450, 440–444 (2007).

    Article  CAS  Google Scholar 

  7. van Leeuwen, F., Gafken, P.R. & Gottschling, D.E. Cell 109, 745–756 (2002).

    Article  CAS  Google Scholar 

  8. Singh, S.K. et al. J. Exp. Med. 210, 987–1001 (2013).

    Article  CAS  Google Scholar 

  9. Mishra, B.P. et al. Cell Rep. 7, 1239–1247 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Patricia Ernst.

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Harte, P., Ernst, P. Harnessing gene repression to inhibit leukemia. Nat Med 21, 308–310 (2015).

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