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Harnessing gene repression to inhibit leukemia

Nature Medicine volume 21, pages 308–310 (2015)Cite this article

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Developing therapeutics for cancers targeting driver mutations in epigenetic regulators is a challenging frontier in cancer therapy. A new study identifies a pathway that, when activated, inhibits the actions of the histone methyltransferase DOT1L in MLL fusion leukemia.

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Figure 1: MLL-AF9 fusion complexes as shown in blue and light blue activate transcription through the recruitment of the H3K79 methylase DOT1L.

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Authors and Affiliations

  1. Peter J. Harte is in the Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.,

    Peter J Harte

  2. Patricia Ernst is in the Departments of Pediatrics and Pharmacology, University of Colorado, Denver/Anschutz Medical Campus, Aurora, Colorado, USA.,

    Patricia Ernst

Authors
  1. Peter J Harte
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  2. Patricia Ernst
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Correspondence to Patricia Ernst.

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The authors declare no competing financial interests.

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Harte, P., Ernst, P. Harnessing gene repression to inhibit leukemia. Nat Med 21, 308–310 (2015). https://doi.org/10.1038/nm.3834

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