Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Understanding Biomarkers of Neurodegeneration: Novel approaches to detecting tau pathology

Tau pathology is commonly analyzed by positron emission tomography (PET) imaging. However, recently developed cell-based techniques for analyzing tau pathogenicity may also be used to measure an early biomarker in tauopathies.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Measuring tau seeding capacity.


  1. Weingarten, M.D., Lockwood, A.H., Hwo, S.Y. & Kirschner, M.W. Proc. Natl. Acad. Sci. USA 72, 1858–1862 (1975).

    CAS  Article  Google Scholar 

  2. Wortmann, M. Alzheimers Res. Ther. 4, 40 (2012).

    PubMed  PubMed Central  Google Scholar 

  3. Murray, M.E. et al. Lancet Neurol. 10, 785–796 (2011).

    Article  Google Scholar 

  4. Small, G.W. et al. N. Engl. J. Med. 355, 2652–2663 (2006).

    CAS  Article  Google Scholar 

  5. Fodero-Tavoletti, M.T. et al. Brain 134, 1089–1100 (2011).

    Article  Google Scholar 

  6. Chien, D.T. et al. J. Alzheimers Dis. 34, 457–468 (2013).

    CAS  Article  Google Scholar 

  7. Maruyama, M. et al. Neuron 79, 1094–1108 (2013).

    CAS  Article  Google Scholar 

  8. Holmes, B.B. et al. Proc. Natl. Acad. Sci. USA 111, E4376–E4385 (2014).

    CAS  Article  Google Scholar 

  9. Yanamandra, K. et al. Neuron 80, 402–414 (2013).

    CAS  Article  Google Scholar 

  10. Morris, J.C. & Price, J.L. J. Mol. Neurosci. 17, 101–118 (2001).

    CAS  Article  Google Scholar 

  11. Villemagne, V.L. et al. Eur. J. Nucl. Med. Mol. Imaging 41, 816–826 (2014).

    CAS  Article  Google Scholar 

  12. Chien, D.T. et al. J. Alzheimers Dis. 38, 171–184 (2014).

    Article  Google Scholar 

  13. Braak, H. & Braak, E. Acta Neuropathol. 82, 239–259 (1991).

    CAS  Article  Google Scholar 

  14. Kfoury, N., Holmes, B.B., Jiang, H., Holtzman, D.M. & Diamond, M.I. J. Biol. Chem. 287, 19440–19451 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Leonard Petrucelli.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Cook, C., Murray, M. & Petrucelli, L. Understanding Biomarkers of Neurodegeneration: Novel approaches to detecting tau pathology. Nat Med 21, 219–220 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing