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Taming the inflammasome

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The NLRP3 inflammasome is involved in the molecular etiology of multiple autoinflammatory diseases. Two studies identify inhibitors of NLRP3 activation and might pave the way for new treatment options for a variety of diseases.

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Figure 1: Inhibitors of the NLRP3 inflammasome.

References

  1. 1

    Henao-Mejia, J., Elinav, E., Thaiss, C.A. & Flavell, R.A. Annu. Rev. Physiol. 76, 57–78 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Jesus, A.A. & Goldbach-Mansky, R. Annu. Rev. Med. 65, 223–244 (2014).

    CAS  Article  Google Scholar 

  3. 3

    Moretti, S. et al. PLoS Pathog. 10, e1004462 (2014).

    Article  Google Scholar 

  4. 4

    Guarda, G. et al. Immunity 34, 213–223 (2011).

    CAS  Article  Google Scholar 

  5. 5

    Juliana, C. et al. J. Biol. Chem. 285, 9792–9802 (2010).

    CAS  Article  Google Scholar 

  6. 6

    Youm, Y.-H. et al. Nat. Med. 20, 263–269 (2015).

    Article  Google Scholar 

  7. 7

    Coll, R.C. et al. Nat. Med. 20, 248–255 (2015).

    Article  Google Scholar 

  8. 8

    Newman, J.C. & Verdin, E. Trends Endocrinol. Metab. 25, 42–52 (2014).

    CAS  Article  Google Scholar 

  9. 9

    Odegaard, J.I. & Chawla, A. Immunity 38, 644–654 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Chang, P.V., Hao, L., Offermanns, S. & Medzhitov, R. Proc. Natl. Acad. Sci. USA 111, 2247–2252 (2014).

    CAS  Article  Google Scholar 

  11. 11

    Jain, N. & Walker, W.A. Gastroenterol. Hepatol. 12, 14–25 (2015).

    CAS  Google Scholar 

  12. 12

    Perregaux, D.G. et al. J. Pharmacol. Exp. Ther. 299, 187–197 (2001).

    CAS  PubMed  Google Scholar 

  13. 13

    Muñoz-Planillo, R. et al. Immunity 38, 1142–1153 (2013).

    Article  Google Scholar 

Download references

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Correspondence to Eran Elinav.

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The authors declare no competing financial interests.

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Levy, M., Thaiss, C. & Elinav, E. Taming the inflammasome. Nat Med 21, 213–215 (2015). https://doi.org/10.1038/nm.3808

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