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Reducing peripheral serotonin turns up the heat in brown fat

Obesity is a major risk factor for chronic disease. A new study in mice reveals that lowering levels of the signaling molecule serotonin outside of the brain reduces obesity and its complications by increasing brown adipose tissue (BAT) energy expenditure.

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Figure 1: Inhibition of peripheral serotonin production protects from diet-induced obesity and related complications.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Bronwyn A Kingwell.

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Carey, A., Kingwell, B. Reducing peripheral serotonin turns up the heat in brown fat. Nat Med 21, 114–116 (2015). https://doi.org/10.1038/nm.3797

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