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A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia

Pathogenic mutations of the genes encoding isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) occur in people with acute myeloid leukemia or other tumors. A new study identifies a dependence of IDH-mutated cells on the anti-apoptosis regulator BCL-2 and indicates a 'synthetic lethal' strategy for the treatment of leukemias.

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Figure 1: Synthetic lethal mechanism of mutant IDH and BCL2 inhibition.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Ulrich Steidl.

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Verma, A., Steidl, U. A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia. Nat Med 21, 113–114 (2015). https://doi.org/10.1038/nm.3796

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