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Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer

Recent studies have suggested that manipulating the tumor-associated macrophage phenotype is a valid therapeutic approach in cancer. In turn, these studies have given some insight into the factors that polarize macrophages, thereby suggesting alternative therapeutic avenues.

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Figure 1: Polarization of tumor associated macrophages.

Katie Vicari / Nature Publishing Group

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Correspondence to Vincenzo Bronte or Peter J Murray.

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Bronte, V., Murray, P. Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer. Nat Med 21, 117–119 (2015). https://doi.org/10.1038/nm.3794

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