Human CD4+ T cells spontaneously detect somatic mutations in cancer cells

CD4+ helper T cells are immune cells that can specifically target cancer cells, but the antigens they recognize on tumor cells are mostly unknown. A new study shows that CD4+ T cells recognize peptides encoded by mutated genes in human melanoma, opening the way for new approaches to cancer immunotherapy.

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Figure 1: Identification of human CD4+ T cells that recognize neoepitopes.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Willem W Overwijk.

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Overwijk, W. Human CD4+ T cells spontaneously detect somatic mutations in cancer cells. Nat Med 21, 12–14 (2015) doi:10.1038/nm.3783

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