Aging platelets stimulate TPO production

The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A new study in mice identifies a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes.

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Figure 1: Regulation of TPO production.

Marina Corral Spence/Nature Publishing Group

References

  1. 1

    Leslie, M. Science 328, 562–564 (2010).

  2. 2

    Kaushansky, K. Blood 111, 981–986 (2008).

  3. 3

    Kuter, D.J. Br. J. Haematol. 165, 248–258 (2014).

  4. 4

    Kuter, D.J., Beeler, D.L. & Rosenberg, R.D. Proc. Natl. Acad. Sci. USA 91, 11104–11108 (1994).

  5. 5

    McCarty, J.M., Sprugel, K.H., Fox, N.E., Sabath, D.E. & Kaushansky, K. Blood 86, 3668–3675 (1995).

  6. 6

    Kaser, A. et al. Blood 98, 2720–2725 (2001).

  7. 7

    Grozovsky, R. et al. Nat. Med. 21, 47–54 (2015).

  8. 8

    Karpatkin, S. & Shulman, S. Trans. Assoc. Am. Physicians 93, 244–250 (1980).

  9. 9

    Grewal, P.K. et al. Nat. Med. 14, 648–655 (2008).

  10. 10

    Kile, B.T. Br. J. Haematol. 165, 217–226 (2014).

  11. 11

    Josefsson, E.C. et al. J. Exp. Med. 208, 2017–2031 (2011).

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Correspondence to Benjamin T Kile.

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Kile, B. Aging platelets stimulate TPO production. Nat Med 21, 11–12 (2015) doi:10.1038/nm.3780

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