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Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

Nature Medicine volume 21, pages 1116–1118 (2015)Cite this article

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Figure 1: Cell isolation with DDX4-specific antibody–based FACS from adult human and mouse ovaries.

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Acknowledgements

This study was supported by grants to O.H. from the Swedish Research Council, the Karolinska Institute and Stockholm County Council Research Funds (ALF); by a grant to L.L. from the Ministry of Science and Technology (MOST) of China National Basic Research Program (2010CB94500); by a grant to F.L. from the Ragnar Söderberg Foundation, the Swedish Research Council (2013-32485-100360-64) and the Swedish Foundation for Strategic Research (ICA12-0001); and by grants to K.L. from the Jane and Dan Olssons Foundation, the LUA/ALF-medel Västra Götalandsregionen, AFA Insurance, the Swedish Research Council and the Swedish Cancer Foundation; and by grants (HIRP100680 and RP110444) to J.-A.G. from the Cancer Prevention & Research Institute of Texas (CPRIT), the Texas Emerging Technology Fund under Agreement no. 300-9-1958, the Robert A. Welch Foundation (grant no. E-0004), and the Swedish Cancer Fund. S. Petropoulos is supported by the Mats Sundin Postdoctoral Fellowship.

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Author notes

  1. Hua Zhang and Sarita Panula: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden

    Hua Zhang, Kiran Busayavalasa, Lian Liu, Xin Li, Sanjiv Risal, Yan Shen, Jingchen Shao & Kui Liu

  2. Division of Obstetrics and Gynecology, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden

    Sarita Panula, Sophie Petropoulos, Romana Raphaela Gerner, Mona Sheikhi, Pauliina Damdimopoulou, Fredrik Lanner & Outi Hovatta

  3. Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden

    Sophie Petropoulos, Daniel Edsgärd & Rickard Sandberg

  4. Cancer Center, Qilu Hospital of Shandong University, Shandong, China

    Lian Liu

  5. Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

    Meng Liu & Susann Li

  6. College of Life Sciences, Nankai University, Tianjin, China

    Dongdong Zhang, Xiaoxi Zhang & Lin Liu

  7. Division of Internal Medicine I (Gastroenterology, Department of Medicine, Endocrinology and Metabolism), Medical University Innsbruck, Innsbruck, Austria

    Romana Raphaela Gerner

  8. Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden

    Pauliina Damdimopoulou

  9. Department of Medicine, Center for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden

    Iyadh Douagi

  10. Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA

    Jan-Åke Gustafsson

Authors
  1. Hua Zhang
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Corresponding authors

Correspondence to Outi Hovatta or Kui Liu.

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Supplementary Methods, Supplementary Figures 1–4 and Supplementary Tables 1–2 (PDF 1275 kb)

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Zhang, H., Panula, S., Petropoulos, S. et al. Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells. Nat Med 21, 1116–1118 (2015). https://doi.org/10.1038/nm.3775

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