Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cell isolation with DDX4-specific antibody–based FACS from adult human and mouse ovaries.


  1. White, Y.A.R. et al. Nat. Med. 18, 413–421 (2012).

    Article  CAS  Google Scholar 

  2. Tanaka, S.S. et al. Genes Dev. 14, 841–853 (2000).

    CAS  Google Scholar 

  3. Noce, T., Okamoto-Ito, S. & Tsunekawa, N. Cell Struct. Funct. 26, 131–136 (2001).

    Article  CAS  Google Scholar 

  4. Woods, D.C. & Tilly, J.L. Nat. Protoc. 8, 966–988 (2013).

    Article  Google Scholar 

  5. Mandelbaum, J. et al. Cancer Cell 18, 568–579 (2010).

    Article  CAS  Google Scholar 

  6. Heidenreich, B., Rachakonda, P.S., Hemminki, K. & Kumar, R. Curr. Opin. Genet. Dev. 24, 30–37 (2014).

    Article  CAS  Google Scholar 

  7. Schmidt, D. et al. Development 131, 933–942 (2004).

    Article  CAS  Google Scholar 

  8. Muzumdar, M.D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. Genesis 45, 593–605 (2007).

    Article  CAS  Google Scholar 

  9. Johnson, J. et al. Cell 122, 303–315 (2005).

    Article  CAS  Google Scholar 

  10. Zou, K. et al. Nat. Cell Biol. 11, 631–636 (2009).

    Article  CAS  Google Scholar 

  11. Handel, M.A., Eppig, J.J. & Schimenti, J.C. Cell 157, 1257–1261 (2014).

    Article  CAS  Google Scholar 

  12. Zhang, H., Adhikari, D., Zheng, W. & Liu, K. Reproduction 146, R229–R233 (2013).

    Article  CAS  Google Scholar 

Download references


This study was supported by grants to O.H. from the Swedish Research Council, the Karolinska Institute and Stockholm County Council Research Funds (ALF); by a grant to L.L. from the Ministry of Science and Technology (MOST) of China National Basic Research Program (2010CB94500); by a grant to F.L. from the Ragnar Söderberg Foundation, the Swedish Research Council (2013-32485-100360-64) and the Swedish Foundation for Strategic Research (ICA12-0001); and by grants to K.L. from the Jane and Dan Olssons Foundation, the LUA/ALF-medel Västra Götalandsregionen, AFA Insurance, the Swedish Research Council and the Swedish Cancer Foundation; and by grants (HIRP100680 and RP110444) to J.-A.G. from the Cancer Prevention & Research Institute of Texas (CPRIT), the Texas Emerging Technology Fund under Agreement no. 300-9-1958, the Robert A. Welch Foundation (grant no. E-0004), and the Swedish Cancer Fund. S. Petropoulos is supported by the Mats Sundin Postdoctoral Fellowship.

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Outi Hovatta or Kui Liu.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Methods, Supplementary Figures 1–4 and Supplementary Tables 1–2 (PDF 1275 kb)

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, H., Panula, S., Petropoulos, S. et al. Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells. Nat Med 21, 1116–1118 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing