Subscribe to Journal
Get full journal access for 1 year
only $18.75 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
White, Y.A.R. et al. Nat. Med. 18, 413–421 (2012).
Tanaka, S.S. et al. Genes Dev. 14, 841–853 (2000).
Noce, T., Okamoto-Ito, S. & Tsunekawa, N. Cell Struct. Funct. 26, 131–136 (2001).
Woods, D.C. & Tilly, J.L. Nat. Protoc. 8, 966–988 (2013).
Mandelbaum, J. et al. Cancer Cell 18, 568–579 (2010).
Heidenreich, B., Rachakonda, P.S., Hemminki, K. & Kumar, R. Curr. Opin. Genet. Dev. 24, 30–37 (2014).
Schmidt, D. et al. Development 131, 933–942 (2004).
Muzumdar, M.D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. Genesis 45, 593–605 (2007).
Johnson, J. et al. Cell 122, 303–315 (2005).
Zou, K. et al. Nat. Cell Biol. 11, 631–636 (2009).
Handel, M.A., Eppig, J.J. & Schimenti, J.C. Cell 157, 1257–1261 (2014).
Zhang, H., Adhikari, D., Zheng, W. & Liu, K. Reproduction 146, R229–R233 (2013).
This study was supported by grants to O.H. from the Swedish Research Council, the Karolinska Institute and Stockholm County Council Research Funds (ALF); by a grant to L.L. from the Ministry of Science and Technology (MOST) of China National Basic Research Program (2010CB94500); by a grant to F.L. from the Ragnar Söderberg Foundation, the Swedish Research Council (2013-32485-100360-64) and the Swedish Foundation for Strategic Research (ICA12-0001); and by grants to K.L. from the Jane and Dan Olssons Foundation, the LUA/ALF-medel Västra Götalandsregionen, AFA Insurance, the Swedish Research Council and the Swedish Cancer Foundation; and by grants (HIRP100680 and RP110444) to J.-A.G. from the Cancer Prevention & Research Institute of Texas (CPRIT), the Texas Emerging Technology Fund under Agreement no. 300-9-1958, the Robert A. Welch Foundation (grant no. E-0004), and the Swedish Cancer Fund. S. Petropoulos is supported by the Mats Sundin Postdoctoral Fellowship.
The authors declare no competing financial interests.
About this article
Cite this article
Zhang, H., Panula, S., Petropoulos, S. et al. Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells. Nat Med 21, 1116–1118 (2015). https://doi.org/10.1038/nm.3775
Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
Nature Communications (2020)
Frontiers in Endocrinology (2019)
Implications and Current Limitations of Oogenesis from Female Germline or Oogonial Stem Cells in Adult Mammalian Ovaries
Extracellular Localisation of the C-Terminus of DDX4 Confirmed by Immunocytochemistry and Fluorescence-Activated Cell Sorting